The small leucine-rich repeat proteins, fibromodulin and osteoadherin, have N- terminal extensions with a variable number of O-sulfated tyrosine residues.
1998-07-03 · Osteoadherin, a Cell-binding Keratan Sulfate Proteoglycan in Bone, Belongs to the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix. *. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3 )-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell
An important paralog of this gene is KERA. Human Osteoadherin/Osteomodulin ELISA Kit from Invitrogen (96 Tests). Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3). Due to OSAD's capacity to bind hydroxyapatite crystals, a role for the protein in the mineralization process has also been suggested.
Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet Osteoadherin is a recently described bone proteogly-can containing keratan sulfate. It promotes integrin (a vb 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847). The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP).
Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin. PRODUCT Each vial contains 200 µg IgG 1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC),
Text is available under the Creative Commons Attribution Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons. It is a member of the Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily. This protein is reported to have a secreted cellular Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h) Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated.
[Y Sommarin, M Wendel, Z Shen, U Hellman, D Heinegârd] PMID 9642227 . Abstract Osteoadherin is a recently described bone … A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA. It was purified to homogeneity using a combination of ion-exchange chromatography, hydroxyapatite chromatography, and gel filtration. The Mr of the proteoglycan was 85,000 as determined by OSTEOADHERIN.
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Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs.
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Although few previous reports show regulation of Omd expression by growth factors and signaling molecules, Rehn et al ( 30 ) reported that transforming growth factor-β (TGF-β) down-regulates Omd 1999-12-30 The Human Osteoadherin IQELISA™ kit is an ultrasensitive ELISA utilizing qPCR detection for 10X more sensitivity with 10X less sample. See more Osteoadherin/OSAD/OMD products: Catalog# EK2017: Storage & Handling: Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.) Description: Sandwich High Sensitivity ELISA kit for Quantitative Detection of human Osteoadherin.
We hypothesized that this domain shares functional properties with heparin
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Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847).
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Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h)
Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC), Current students New students International Desk Academic matters & support IT services & support Careers Service Osteoadherin staining was strong in the whole odontoblast layer (with a slight to the surrounding predentin/dentin/pulp matrix, possibly through osteoadherin. Osteomodulin (OMD), also called osteoadherin, belongs to the family of leucine- rich repeat proteins (SLRPs) of the extracellular matrix, which have crucial roles 人Osteoadherin ELISA for serum, plasma and cell culture supernatants; find Sigma-Aldrich-RAB1619 MSDS, related peer-reviewed papers, technical May 4, 1998 A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine Mar 20, 2003 Osteoadherin (OSAD) is a keratan sulfate‐containing proteoglycan, belonging to the small leucine‐rich proteoglycan (SLRP) family.
2012-02-15 · Osteoadherin (OSAD), a 47 kDa KS-SLRP, was identified and purified from bovine long bones by Wendel et al. and was found specifically located to mineralized tissues , . The function of OSAD during mineralization remains to be fully elucidated; however it has been shown to have a high affinity for hydroxyapatite, via the large and acidic C-terminal [15] , [16] .
Utility Header Menu Right. 800-343-7475; Contact Us; Cart Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin. PRODUCT Each vial contains 200 µg IgG 1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC), Current students New students International Desk Academic matters & support IT services & support Careers Service Osteoadherin staining was strong in the whole odontoblast layer (with a slight to the surrounding predentin/dentin/pulp matrix, possibly through osteoadherin. Osteomodulin (OMD), also called osteoadherin, belongs to the family of leucine- rich repeat proteins (SLRPs) of the extracellular matrix, which have crucial roles 人Osteoadherin ELISA for serum, plasma and cell culture supernatants; find Sigma-Aldrich-RAB1619 MSDS, related peer-reviewed papers, technical May 4, 1998 A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine Mar 20, 2003 Osteoadherin (OSAD) is a keratan sulfate‐containing proteoglycan, belonging to the small leucine‐rich proteoglycan (SLRP) family. In bone Aug 6, 2009 Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation.
2017-02-28 Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is encoded by the OMD gene. References Further reading. This page was last edited on 12 October 2020, at 04:35 (UTC). Text is available under the Creative Commons Attribution Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons. It is a member of the Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily. This protein is reported to have a secreted cellular Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h) Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.